Analysis of Adeno-associated virus (AAV) by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0749-WXH)

Introduction

Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They are small (approximately 26 nm in diameter) replication-defective, nonenveloped viruses and have linear single-stranded DNA (ssDNA) genome of approximately 4.8 kilobases (kb).
AAV are not currently known to cause disease. The viruses cause a very mild immune response. Several additional features make AAV an attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell.