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Official Full Name: aryl hydrocarbon receptor nuclear translocator
Also known as: ARNT1; HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
The protein encoded by this gene contains a basic helix-loop-helix domain and two characteristic PAS domains and a PAC domain. The encoded protein binds to the ligand-bound aryl hydrocarbon receptor and helps the complex move to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a cofactor in the transcriptional regulation of hypoxia-inducible factor 1. A chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 has been described in leukemia. Alternative splicing results in multiple transcript variants.