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Official Full Name: ATPase H+ transporting V1 subunit G3
Also known as: Vma10; ATP6G3
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles in eukaryotic cells. V-ATPase-dependent acidification of organelles is essential for intracellular processes such as protein sorting, zymogen activation, receptor-mediated endocytosis, and generation of synaptic vesicle proton gradients. V-ATPase consists of a cytoplasmic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus C, D, E, F and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain is composed of 5 distinct subunits: a, c, c', c' and d. Other isoforms of many V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants of this gene have been found to encode different isoforms.