Unlock Exclusive Discounts & Flash Sales! Click Here to Join the Deals on Every Wednesday!
Official Full Name: basic helix-loop-helix ARNT like 1
Also known as: TIC; JAP3; MOP3; ARNTL; PASD3; ARNTL1; BMAL1c; bHLHe5
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds to E-box enhancer elements upstream of period genes (PER1, PER2, PER3) and cryptochrome genes (CRY1, CRY2), activating the transcription of these genes. PER and CRY proteins repress their own transcription by interacting with the CLOCK/ARNTL complex in a feedback loop. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infections, including COVID-19.