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Official Full Name: bone morphogenetic protein receptor type 1A
Also known as: ALK3; SKR5; ALK-3; CD292; ACVRLK3; BMPR-1A; 10q23del
Bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors ACVR1 and ACVR2. The ligands for these receptors are members of the TGF-β superfamily. TGF-β and activin signal by forming a heterocomplex with two different types of serine (threonine) kinase receptors: a type I receptor of about 50-55 kd and a type II receptor of about 70-80 kd. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling and type I receptors require their respective type II receptors for ligand binding.