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Official Full Name: C-C motif chemokine ligand 27
Also known as: ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunomodulatory and inflammatory processes. CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene has chemotactic effect on skin-associated memory T lymphocytes. This cytokine may also play a role in mediating the homing of lymphocytes to skin sites. It specifically binds chemokine receptor 10 (CCR10). Studies of similar mouse proteins revealed that these protein-receptor interactions play a key role in T cell-mediated skin inflammation.