Unlock Exclusive Discounts & Flash Sales! Click Here to Join the Deals on Every Wednesday!
CD117 is also known as c-Kit, Steel factor receptor, and stem cell factor receptor. This tyrosine kinase protein is mainly expressed in hematopoietic progenitor cells, mast cells, and acute myeloid leukemia cells (AML). CD117 activation promotes proliferation and differentiation of these cell subtypes. The absence or deficiency of stem cell factors can result in a decreased number of hematopoietic progenitor cells and severe anemia. CD117 is also expressed by melanocytes and plays a role in signaling and activation in these cells.