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The human CD14 gene is located on chromosome 5 at locus 5q23-31. According to the cDNA sequence of CD14, CD14 is composed of 356 amino acids. After the ribosome synthesizes the polypeptide, it is transported to the Golgi complex for glycosylation reaction, so CD14 is a glycoprotein. It was initially confirmed that CD14 is a myeloid differentiation antigen that exists in mature myeloid cells, while immature myeloid cells do not have CD14.