Analysis of CDKN2C Gene (Mutation) in Multiple Myeloma by RT-qPCR (CAT#: STEM-MT-0108-LGZ)

Introduction

Also known as: p18; INK4C; p18-INK4C<br />The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6 and prevent the activation of CDK kinases, thus functioning as a cell growth regulator controlling cell cycle G1 progression. Ectopic expression of this gene inhibits human cell growth in a manner that appears to be correlated with the presence of wild-type RB1 function. Studies in knockout mice have shown a role for this gene in regulating spermatogenesis as well as suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, encoding the same protein, have been reported.