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Official Full Name: cadherin EGF LAG seven-pass G-type receptor 2
Also known as: EGFL2; MEGF3; ADGRC2; CDHF10; Flamingo1
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The subfamily of flamingos consists of nonclassical cadherins; a subpopulation that does not interact with catenin. Flamingo-cadherin is located on the plasma membrane and has nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A-G-type repeats. They also have seven transmembrane domains, a feature unique to this subfamily. These proteins are postulated to be receptors involved in contact-mediated communication, with the cadherin domain serving as the homophilic binding domain and the EGF-like domain involved in cell adhesion and receptor-ligand interactions. The exact function of this particular member has not been determined.