Analysis of TRPM5 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2176-LGZ)

Introduction

Official Full Name: transient receptor potential cation channel subfamily M member 5<br />Also known as: MTR1; LTRPC5<br />This gene encodes a member of the transient receptor potential (TRP) protein family, a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction and has the characteristics of a calcium-activated non-selective cation channel, which can simultaneously carry Na+, K+ and Cs+ ions, but cannot carry Ca(2+) ions. It is activated by low concentrations of intracellular Ca(2+) and inhibited by high concentrations of Ca(2+). It is also a highly temperature-sensitive thermally activated channel, with a sharp increase in inward current at temperatures between 15 and 35 degrees Celsius. The gene is located in the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5 and has been shown to be imprinted, expressed only by the paternal allele.