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Endoglin, also known as CD105, is a type I transmembrane glycoprotein located on the surface of the cell membrane and is one of the TGF-β receptor complexes. It is involved in the regulation of responses binding to TGF-β1, TGF-β3, Activin-A, BMP-2 and BMP-7. Endoglin is speculated to be involved in the formation of the cytoskeleton affecting cell morphology and migration. It plays a role in cardiovascular system development and vascular remodeling.