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erb-B2 (tyrosine kinase receptor 2, also known as NEU, CD340) is a 185kDa cell membrane receptor encoded by the proto-oncogene erbB-2, and is a member of the epidermal growth factor receptor (EGFR) family. The high expression of erb-B2 makes the cell proliferation ability stronger, the differentiation maturation and apoptosis mechanism are inhibited, and the cell malignancy is high.