Analysis of FMO2 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1001-LGZ)

Introduction

Official Full Name: flavin containing dimethylaniline monoxygenase 2
Also known as: FMO1B1
This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants.