Analysis of Furin by ELISA (CAT#: STEM-MB-1522-LGZ)

Introduction

Furin protease (Furin) is a type I transmembrane protein composed of 794 amino acid residues, which is named for its gene (fur) located upstream of the proto-oncogene fes/feps. Its main structures include signal peptide, precursor peptide, Subtilis proteasin-like catalytic domain, P- domain, cysteine-rich domain, hydrophobic C-terminal transmembrane domain and C-terminal cytoplasmic domain composed of 58 residues. As a major protein invertase in exogenic pathways, Furin is localized in a network on the lateral side of the Golgi apparatus. Flynn protease plays an important role in embryogenesis and homeostasis and has been implicated in various pathologies such as cancer, neurodegenerative diseases, and anthrax. In addition, Furin is not only involved in the processing of various precursor proteins and the maturation of many growth factors, but also involved in many diseases, such as infection caused by the novel coronavirus, bone-related diseases and tumors, and has important biological functions.