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GDF15 is a biomarker for cancer diagnosis, disease progression and prognosis. Its levels are elevated in multiple solid tumor cancer types, and it is a diagnostic biomarker for pancreatic, bowel, ovarian, prostate, primary liver, and lung cancer. It was associated with disease progression, prognosis, and overall survival of a variety of cancers, including colorectal cancer, gastric cancer, hepatocellular carcinoma, non-small cell lung cancer, urothelial/renal cell carcinoma, ovarian cancer, and breast cancer, but not with hematologic tumors.