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Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily expressed in human granulosa cells and plays an important role in regulating various functions of the ovary. GDF8 is a negative regulator of skeletal muscle growth and differentiation. In addition to being expressed in the musculoskeletal system, GDF8 is also expressed in various tissues including the reproductive system.