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Immunoglobulin G (IgG) is a type of antibody produced and released by plasma B cells. IgG is the main type of antibody in blood and extracellular fluid, which can control the infection of human tissue. Antibodies protect the body from infection by binding to many pathogens, such as viruses, bacteria and fungi. In humans, IgG has four subtypes IgG1, IgG2, IgG3 and IgG4. In mice and rats, IgG also has four subtypes—IgG1, IgG2a, IgG2b, and IgG3.