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Official Full Name: immunoglobulin superfamily member 8<br />Also known as: EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1<br />This gene encodes a member of the EWI subfamily of the immunoglobulin superfamily. Members of this family contain a transmembrane domain, an EWI (Glu-Trp-Ile) motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their roles in certain cellular functions, including cell migration and viral infection. The encoded protein may also act as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants encoding the same protein.