Analysis of KCNA2 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0123-LGZ)

Introduction

Also known as: HK4; MK2; HBK5; NGK1; RBK2; DEE32; HUKIV; KV1.2; EIEE32<br />Potassium ion channels are the most complex class of voltage-gated ion channels from both functional and structural point of view. Their diverse functions include regulation of neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes—shaker, shaw, shab, and shall—were found in Drosophila and each had human orthologs. This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six transmembrane domains with a shaker-type repeat in the fourth segment. It belongs to the class of delayed rectifiers, members of which allow nerve cells to efficiently repolarize following an action potential. There is no intron in the coding region of this gene, and it is clustered on chromosome 1 with KCNA3 and KCNA10 genes.