Analysis of LITAF Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2475-LGZ)

Introduction

Official Full Name: lipopolysaccharide induced TNF factor<br />Also known as: PIG7; SIMPLE; TP53I7<br />Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing the secretion of tumor necrosis factor-α (TNF-α) and other inflammatory mediators. The gene encodes lipopolysaccharide-induced tnf-alpha factor, which is a dna-binding protein and can mediate the expression of tnf-alpha by directly binding to the promoter region of tnf-alpha gene. The transcription of this gene is induced by the tumor suppressor p53 and is related to the p53-induced apoptosis pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.