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Monocyte chemotactic proteins (MCPs) are a series of cytokines with similar structure, molecular mass about 8-10kD, and chemotactic function. They all contain 4 cysteines and form two internal disulfide bonds, and belong to the CC subfamily (β subfamily) of chemokines, including MCP-1, MCP-2, MCP-3, MCP-4, MCP-5. MCPs and their receptors play important roles in immune regulation, organogenesis, modulation of hematopoiesis, and neuronal communication. MCP-4 (CCL13) is a potent eosinophil-attractant factor.