Analysis of metallic nanoparticles by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0733-WXH)

Introduction

Metallic nano particle is nano sized metals with dimensions (length, width, thickness) within the size range of 1-100nm. In 1857, Faraday first investigated the existence of metallic nano particles in solution. Today these nano materials can be prepared and modified with various chemical functional groups which allow them to bind with antibodies, ligands and drugs. Metallic nanoparticles give wide range of application in therapeutic area, biotechnology, vehicles for gene and drug delivery.

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Principle Applications Procedure Materials Notes Related Products

Principle

Nanoparticle tracking analysis (NTA) is a method for visualizing and analyzing particles in liquids that relates the rate of Brownian motion to particle size. The rate of movement is related only to the viscosity and temperature of the liquid; it is not influenced by particle density or refractive index. NTA allows the determination of a size distribution profile of small particles with a diameter of approximately 10-1000 nanometers (nm) in liquid suspension.

Applications

NTA has been used by commercial, academic, and government laboratories working with nanoparticle toxicology, drug delivery, exosomes, microvesicles, bacterial membrane vesicles, and other small biological particles, virology and vaccine production, ecotoxicology, protein aggregation, orthopedic implants, inks and pigments, and nanobubbles.

Procedure

1. Sample preparation
2. Nanoparticle Tracking Analysis
3. NTA Data Processing, Display, and Interpretation

Materials

• Nanoparticle Tracking Analysis (NTA) instrument
• NanoSight instrument
• Nanoparticle Analyzer

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