Analysis of MICA by ELISA (CAT#: STEM-MB-1523-LGZ)

Introduction

MHC Class I polypeptide-related Sequence A is a protein encoded by the MICA gene in humans. MICA is minimally expressed in normal cells, but is often expressed or shed in epithelial tumors and can be induced by bacterial and viral infections. In recent years, the activation pathway of NKG2D receptor represented by MICA and the mutual regulatory mechanism between the two have received extensive attention in the research fields of tumor immunity, autoimmunity and anti-infection immunity. This membrane protein molecule can bind to the NKG2D receptor on the surface of NK cells, thus activating the killing activity of NK cells. The identification of MICA involves tumor surveillance, viral infections, and autoimmune diseases. The distribution characteristics of MICA gene were related to geographical and population factors, and the distribution frequency of alleles was different among different populations.