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Midkine (MK or MDK) is a 15 kDa heparin-binding molecule, also known as axon growth Promotion Factor 2 (NEGF2), which is a protein encoded by the MDK gene. Midkine is pleiotropic and can play a role in cell proliferation, cell migration, angiogenesis and fibrinolysis. Midkine expression has been found in various cancer types, such as neuroblastoma, colorectal cancer, liver cancer and ovarian cancer. The serum concentration of Midkine in patients with these malignant tumors is much higher than that of normal people. In some cases, these high concentrations of Midkine also predict a poorer prognosis for diseases such as neuroblastoma, glioma, and bladder cancer. Midkine acts as a low-affinity receptor that binds to nucleolins on the cell surface. This combination can inhibit HIV infection.