Unlock Exclusive Discounts & Flash Sales! Click Here to Join the Deals on Every Wednesday!
Official Full Name: neutrophil cytosolic factor 2<br />Also known as: NCF-2; NOXA2; P67PHOX; P67-PHOX<br />This gene encodes neutrophil cytoplasmic factor 2, the 67 kilodalton cytoplasmic subunit of the multiprotein NADPH oxidase complex found in neutrophils. This oxidase generates large amounts of superoxide, which is transported into the lumen of the neutrophil phagosome. Mutations in this gene, as well as mutations in other NADPH oxidase subunits, cause chronic granulomatous disease, which causes recurrent infections with catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.