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Neurotrophin-3, NT-3, is a member of the nerve growth factor family. The sequences of human and rat, mouse and pig are identical. NT-3 plays an important role in the development and maintenance of neural cell populations. Can promote the differentiation of sensory neurons and sympathetic neurons. NT-3 is a dimer composed of 119 amino acid chains with a molecular weight of 27KDa. NT-3 binds p75-NGFR, and initiates apoptosis. Its activating signaling occurs through the TrkC receptor.