Analysis of β-NGF (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0638-LGZ)

Introduction

Nerve growth factor (NGF) is a neuropeptide that is mainly involved in regulating the growth, proliferation and survival of certain target neurons. When expressed, NGF initially exists as a 7S, 130 kDa complex consisting of three proteins, α-NGF, β-NGF, and γ-NGF (2:1:2 ratio). "Nerve growth factor" generally refers to a 2.5S, β subunit protein with a molecular weight of 26 kDa. The β subunit is the only biologically active component (eg, as a signaling molecule) of the 7SNGF complex. NGF plays an important role in both innate and acquired immunity. Studies have shown that NGF circulates in the body through plasma and is important for the maintenance of overall homeostasis. NGF can promote the repair of myelin, and can also participate in a variety of mental diseases, such as Alzheimer's disease, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa. Dysregulation of NGF signaling is associated with Alzheimer's disease. Likewise, NGF plays a role in many cardiovascular diseases such as coronary atherosclerosis, obesity, type 2 diabetes, metabolic syndrome. NGF also promotes wound healing.