Analysis of NPR1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0502-LGZ)

Introduction

Official Full Name: natriuretic peptide receptor 1
Also known as: ANPa; NPRA; ANPRA; GUC2A; GUCY2A
Guanidyl cyclases that catalyze GTP to cGMP are divided into soluble and membrane forms (Garbers and Lowe,). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that con tains a protein kinase -like domain and a cyclase catalytic domain. GC-A and GC-B act as natriuretic peptide receptors; they are also known as atrial natriuretic peptide receptors A (NPR1) and B (NPR2); MIM 108961). See also NPR3 (MIM 108962), which encodes a protein with only a ligand-binding transmembrane and a 37 amino acid cytoplasmic domain. NPR1 is a membrane-bound guanylate cyclase that acts as a receptor for atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295).