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Official Full Name: NSL1 component of MIS12 kinetochore complex
Also known as: DC8; MIS14; C1orf48
The gene encodes a protein with two coiled domains that localize to centromeres, chromosome-associated structures that attach to microtubules and mediate chromosome movement during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the kinetochore outer plate. This protein complex is thought to act as a bridge connecting centromere heterochromatin and outer centromere structures. Multiple transcript variants of this gene have been found encoding different isoforms. The 3'UTR region of this gene has a pseudogene on the X chromosome.