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Detection of serum markers is one of the important means of early diagnosis and prognosis of heart failure. Among them, natriuretic peptide (a marker of activation of neuroendocrine system), including cerebrouretic natriuretic peptide (BNP) and amino terminal cerebral natriuretic peptide (NT-proBNP), is the preferred serum marker for heart failure recommended by both domestic and foreign heart failure guidelines (ECS/ACC/AHA/HFSA/CSC).