Analysis of OGG1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1826-LGZ)

Introduction

Official Full Name: 8-oxoguanine DNA glycosylase
Also known as: HMMH; MUTM; OGH1; HOGG1
This gene encodes the enzyme responsible for cleaving 8-oxoguanine, a mutagenic byproduct of exposure to reactive oxygen species. The action of this enzyme includes the activity of lyase to cleave strands. Alternative splicing of the C-terminal region of this gene divides splice variants into two major categories, type 1 and type 2, based on the last exon of the sequence. Type 1 alternative splice variants end in exon 7 and type 2 end in exon 8. All variants share a common N-terminal region that contains the mitochondrial targeting signal, which is critical for mitochondrial localization. Many alternative splice variants of this gene have been described, but the full-length nature of each variant has not been determined.