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Official Full Name: peptidyl arginine deiminase 2<br />Also known as: PAD2; PDI2; PAD-H19<br />This gene encodes a member of the peptidylarginine deiminase family that catalyzes the post-translational deimination of proteins by converting arginine residues to citrulline in the presence of calcium ions. Family members have distinct substrate specificity and tissue-specific expression patterns. Type II enzymes are the most widely expressed family members. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the initiation and progression of neurodegenerative human diseases, including Alzheimer's disease and multiple sclerosis, and it has also been implicated in the pathogenesis of glaucoma. This gene exists in a cluster with four other homologous genes.