Analysis of UGT1A8 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1529-LGZ)

Introduction

Official Full Name: UDP glucuronosyltransferase family 1 member A8
Also known as: GNT1; UGT1; UDPGT; UGT1A; UGT1H; UGT-1A; UGT-1H; UGT1.1; UGT1.8; UGT1A1; UGT1-01; UGT1-08; UGT1A8S; hUG-BR1; UDPGT 1-1; UDPGT 1-8
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus encoding several UDP-glucosyltransferases. This locus consists of 13 unique alternating first exons followed by 4 common exons. Four alternating first exons are considered pseudogenes. Each of the remaining 9 5' exons could potentially splice with 4 common exons, resulting in 9 proteins with different n-termini and identical c-termini. Each first exon encodes a substrate binding site and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity and can degrade a variety of substrates, including coumarins, phenols, anthraquinones, flavonoids, and some opioids.