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Official Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2<br />Also known as: PFK-2/FBPase-2<br />The protein encoded by this gene is involved in the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule controlling glycolysis in eukaryotes. The encoded protein has 6-phosphofructose-2 kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and fructose-2,6-bisphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while related enzymes encoded by different genes regulate fructose-2,6-bisphosphate levels in the liver and muscles. This enzyme acts as a homodimer. Two transcript variants of this gene have been found encoding two different isoforms.