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Peroxiredoxin 6 (Prdx-6) belongs to the non-selenoperoxidase (prdx) family of antioxidant enzymes. It is the only member of the Prdx family that possesses both glutathione peroxidase and phospholipase A2 activities. Prdx-6 regulates phospholipid turnover and protects cells from oxidative damage. Prdx6 is expressed in all major organs, with particularly high expression levels in lung cells, and regulates lung surfactant phospholipid synthesis and metabolic turnover.