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Official Full Name: protein kinase AMP-activated non-catalytic subunit beta 2
The protein encoded by this gene is the regulatory subunit of AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of a catalytic alpha subunit and noncatalytic beta and gamma subunits. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthes is fatty acid and cholesterol . This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific effects. Multiple alternatively spliced transcript variants have been found for this gene.