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Also known as: PTC2<br />This gene encodes a transmembrane receptor of a patch gene family. The encoded protein may play a tumor suppressor role in the hedgehog signaling pathway. Alterations in this gene have been associated with susceptibility to neoplastic basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and congenital macrostomia. Alternative spliced transcript variants have been described.