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Official Full Name: RAN binding protein 2
Also known as: ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358
RAN is a small GTP-binding protein in the RAS superfamily associated with the nuclear membrane and thought to control a variety of cellular functions through interactions with other proteins. This gene encodes a very large ran-binding protein that immunolocalizes to the nuclear pore complex. This protein is a giant scaffold and mosaic cyclophilin-associated nucleoporin that is involved in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly promotes the transfer of SUMO1 from UBC9 to the SUMO1 target SP100. These findings place polymerization on the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are related events. The gene is partially duplicated in a gene cluster located at a recombination hotspot on chromosome 2q.