Analysis of RPS27 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0640-LGZ)

Introduction

Official Full Name: ribosomal protein S27<br />Also known as: S27; MPS1; eS27; DBA17; MPS-1<br />The ribosome is an organelle that catalyzes protein synthesis and consists of a small 40S subunit and a large 60S subunit. These subunits consist of four RNAs and about 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and a component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain, which can bind zinc and nucleic acid. Mutations in this gene have been found in many melanoma patients and at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As a typical gene encoding ribosomal proteins, multiple processing pseudogenes of this gene are scattered throughout the genome.