Analysis of SETX Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1945-LGZ)

Introduction

Official Full Name: senataxin
Also known as: ALS4; AOA2; STEX; Sen1; SCAN2; SCAR1; bA479K20.2
This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).