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Official Full Name: SLAM family member 6
Also known as: KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000
The protein encoded by this gene is a type I transmembrane protein belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer cells (NK), T lymphocytes and B lymphocytes. It undergoes tyrosine phosphorylation and is associated with Src homology 2 domain protein (SH2D1A) and SH2 domain containing phosphatases (SHPs). It functions as a co-receptor during NK cell activation. It also mediates inhibitory signaling in NK cells from patients with X-linked lymphoproliferative disease. Alternative splicing results in multiple transcript variants encoding different isoforms.