Analysis of SPEN Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1423-LGZ)

Introduction

Official Full Name: spen family transcriptional repressor<br />Also known as: MINT; SHARP; RATARS; RBM15C; HIAA0929<br />This gene encodes a hormone-induced transcriptional repressor. Transcriptional repression of this gene product can be achieved through interactions with other repressors, through recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that allows binding to other corepressor proteins. This domain also allows interaction with members of the NuRD complex, a nucleosome remodeling protein complex with sirtuin activity. Furthermore, this suppressor contains several RNA recognition motifs that confer binding to steroid receptor RNA coactivators; this binding can modulate the activity of both liganded and unliganded steroid receptors.