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As an important protective factor of gastrointestinal mucosa, TFF3 is closely related to the injury, repair, proliferation and malignancy of gastrointestinal mucosa. TFF3 has a certain relationship with the occurrence, development and prognosis of tumors. However, the binding protein of TFF3 has not been clarified, and its intracellular mechanism of action and specific signal transduction pathways are still in the initial stage.