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Thrombospondin-1 (THBS-1) is a member of the thrombospondin family that mediates cell-cell and cell-matrix interactions. This protein binds to fibrinogen, fibronectin, laminin, collagen type V and integrin α-V/β-1. It plays a role in platelet aggregation, angiogenesis and tumorigenesis. In normal tissues, it is a natural inhibitor of neovascularization and tumorigenesis. THBS-1 also positively and negatively regulates endothelial cell adhesion, motility and growth. By blocking the binding of THBS-1 to the cell surface receptor (CD47), normal tissues are almost immune to tumor radiation therapy and contribute to tumor death.