Analysis of B7-1/CD80 by ELISA (CAT#: STEM-MB-1558-LGZ)

Introduction

Antigen-differentiated Cluster 80 (CD80) is a protein found on dendritic cells, activated B cells, and monocytes that provides the necessary co-stimulatory signals for T cell activation and survival. It's also known as B7-1. The cDNA of B7-1 is predicted to be a type I membrane protein, a membrane protein synthesized on a signal peptide translocated on the endoplasmic membrane. The protein was predicted to contain two extracellular domains, whose structures were similar to Ig, hydrophobic transmembrane domain and short cytoplasmic domain. The CD80 and CD86 genes encode B7-1 and B7-2, respectively, and are structurally similar members of the immunoglobulin superfamily expressed on various hematopoietic cell types. B7-1 and B7-2 provide co-stimulatory signals to T cells by interacting with CD28 and CTLA4.