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Official Full Name: TNF receptor superfamily member 9
Also known as: ILA; 4-1BB; CD137; CDw137; IMD109
The protein encoded by this gene is a member of the TNF receptor superfamily. This receptor contributes to the clonal expansion, survival and development of T cells. It can also induce peripheral mononuclear cell proliferation, enhance TCR/CD3 trigger activation-induced T cell apoptosis, and regulate CD28 co-stimulation to promote Th1 cell response. Expression of this receptor is induced by lymphocyte activation. TRAF adapter proteins have been shown to bind to this receptor and transduce signals leading to NF-kappaB activation.