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Official Full Name: troponin I1, slow skeletal type
Also known as: TNN1; SSTNI
Troponin associates with tropomyosin and regulates calcium sensitivity of striated muscle myofibrillar retractors. Troponin I (TnI), together with troponin T (TnT) and troponin C (TnC), is one of three subunits that form the troponin complex in striated muscle filaments. TnI is an inhibitory subunit; blocks actin-myosin interactions, thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-fast skeletal twitch, TnI-slow skeletal twitch, and TnI-cardiac. TnI-fast and TnI-slow genes were expressed in fast-twitch skeletal muscle fibers and slow-twitch skeletal muscle fibers respectively, while TnI-cardiac gene was only expressed in myocardial tissue. This gene encodes troponin-1-skeletal slow-twitch protein. The gene is expressed in early developing heart and skeletal muscle, but only in adult slow-twitch skeletal muscle fibers. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes of the actin-myosin complex.