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Also known as: TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; CMYP4A; CMYP4B; TM30nm; TPM3nu; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5<br />This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosin is a dimer of Frizzled protein that provides stability to actin filaments and regulates the entry of other actin-binding proteins. Mutations in this gene cause autosomal dominant linear myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), resulting in the formation of fusion proteins that act as oncogenes. This gene has many pseudogenes on different chromosomes. Alternative splicing results in multiple transcript variants.