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Official Full Name: nectin cell adhesion molecule 4<br />Also known as: LNIR; PRR4; EDSS1; PVRL4; nectin-4<br />This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single generation type I membrane protein. The soluble form is produced by proteolytic cleavage of the cell surface by the metalloprotease ADAM17/TACE. The secreted form has been found both in breast tumor cell lines and in patients with breast tumors. Mutations in this gene are responsible for ectodermal dysplasia - and referred to as syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been identified, but the full-length nature of the variants has not been determined.